Viruses and Targets
The Projects in MAVDA will focus on unique and complementary approaches to develop, characterize, and optimize small molecules for the treatment of SARS-CoV-2, other CoVs, as well as additional RNA virus families of pandemic potential. The viruses and targets covered under the program are listed below.
Virus Family: Coronaviridae
SARS-CoV-2
HCoV-NL63
HCoV-229E
HCoV-0C43
MERS
Virus Family: Flaviviridae
DENV1-4
ZIKV
WNV
YFV
POWV
LGTV
Virus Family: Poxviridae
MPV
Virus Family: Togaviridae
CHIKV
EEEV
SINV
VEEV
SFV
RRV
MAYV
ONNV
Virus Family: Bunyaviridae
LACV
Targets:
3CL pro (Mpro)
NiRAN
NSP14 Methylase
PL pro; Helicase
RdRp
Exonuclease