Viruses and Targets   

Viruses and Targets

The Projects in MAVDA will focus on unique and complementary approaches to develop, characterize, and optimize small molecules for the treatment of SARS-CoV-2, other CoVs, as well as additional RNA virus families of pandemic potential. The viruses and targets covered under the program are listed below.
Virus Family: Coronaviridae

SARS-CoV-2
HCoV-NL63
HCoV-229E
HCoV-0C43
MERS

Virus Family: Flaviviridae

DENV1-4
ZIKV
WNV
YFV
POWV
LGTV

Virus Family: Poxviridae

MPV

Virus Family: Togaviridae

CHIKV
EEEV
SINV
VEEV
SFV
RRV
MAYV
ONNV

Virus Family: Bunyaviridae

LACV

Targets:

3CL pro (Mpro)
NiRAN
NSP14 Methylase
PL pro; Helicase
RdRp
Exonuclease

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